J Interdiscip Dentistry
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Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 25-29

Immunolocalization of c-Fos, c-Jun and Fra-2 in healthy human marginal gingival tissues

Department of Histology and Embryology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey

Correspondence Address:
Nurullah Keklikoglu
Department of Histology and Embryology, Faculty of Dentistry, Istanbul University, Istanbul
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Source of Support: The Research Fund of the Istanbul University (Project number: BYP-762/23082005)., Conflict of Interest: None

DOI: 10.4103/2229-5194.94188

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Background and Objective: Keeping marginal gingiva healthy is possible with some cellular processes. Activator Protein-1 (AP-1) members Fos and Jun proteins regulate cellular processes including growth, proliferation, differentiation and apoptosis. The aim of this study was to compare of immunoreactivity (IR) of some same or different family member AP-1 proteins in cells forming marginal gingival mucosa. Materials and Methods: IR of Fos family members c-Fos (c-Fos-IR) and Fra-2 (Fra-2-IR) and Jun family member c-Jun (c-Jun-IR) were analysed in epithelial cells (ECs) and lamina propria cells (LPCs) of healthy human marginal gingiva by immunohistochemical method. Results: Both in ECs and LPCs, c-Fos-IR positivity was found higher than the others and Fra-2-IR positivity was found lower. The most postivity was observed in c-Fos-IR in ECs and the least IR was observed in Fra-2-IR in LPCs. Furthermore, the IR positivity percentage of all proteins was found higher in ECs than in LPCs. In the comparision of each of c-Fos-IR, c-Jun-IR and Fra-2-IR in ECs and LPCs, no statistically significant difference in c-Jun-IR was observed; however, there were statistically significant differences in c-Fos-IR and Fra-2-IR. Conclusions: According to these findings, it can be proposed that c-Fos protein in healthy gingiva is more related with physiological processes than other proteins. In this study, establishing a statistically significant difference between c-Fos-IR and Fra-2-IR in both ECs and LPCs has shown that as well as these proteins are within the same family, each one may be related with different cellular processes.

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